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1884 – U.S. Representative John R. Lynch of Mississippi (thought to be the first keynote speaker) (Keynote speakers)
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1916 – U.S. Senator Warren G. Harding of Ohio (Keynote speakers)
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1920 – U.S. Senator Henry Cabot Lodge of Massachusetts (Keynote speakers)
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1924 – U.S. Representative Theodore Burton of Ohio (Keynote speakers)
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1928 – U.S. Senator Simeon Fess of Ohio (Keynote speakers)
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1932 – U.S. Senator Lester Dickinson of Iowa (Keynote speakers)
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1936 – U.S. Senator Frederick Steiwer of Oregon (Keynote speakers)
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1940 – Governor Harold Stassen of Minnesota (Keynote speakers)
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1944 – Governor Earl Warren of California (Keynote speakers)
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1948 – Governor Dwight Green of Illinois (Keynote speakers)
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1952 – General Douglas MacArthur of Wisconsin (Keynote speakers)
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1956 – Governor Arthur Langlie of Washington (Keynote speakers)
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1960 – U.S. Representative Walter Judd of Minnesota (Keynote speakers)
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1964 – Governor Mark Hatfield of Oregon (Keynote speakers)
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1968 – Governor Daniel Evans of Washington (Keynote speakers)
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1972 – RNC Co-Chair Anne Armstrong of Texas (Keynote speakers)
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1976 – U.S. Senator Howard Baker of Tennessee (Keynote speakers)
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1980 – U.S. Representative Guy Vander Jagt of Michigan (Keynote speakers)
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1984 – U.S. Treasurer Katherine Ortega of New Mexico (Keynote speakers)
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1988 – Governor Thomas Kean of New Jersey (Keynote speakers)
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1992 – U.S. Senator Phil Gramm of Texas (Keynote speakers)
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1996 – U.S. Representative Susan Molinari of New York (Keynote speakers)
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2000 – No officially designated keynote speaker; U.S. Senator John McCain of Arizona and General Colin Powell of Virginia were featured speakers. (Keynote speakers)
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2004 – U.S. Senator Zell Miller of Georgia (a Democrat, Miller is first speaker from the opposite party to address a national convention as keynoter) (Keynote speakers)
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2008 – Mayor Rudy Giuliani of New York (Keynote speakers)
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2012 – Governor Chris Christie of New Jersey (Keynote speakers)
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2016 – No officially designated keynote speaker; multiple "headliners" each night (Keynote speakers)
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